Multiscale OCT imaging for high-throughput assessment of oocytes and embryos
Camard et al., 2024
Current microscopes used in IVF laboratories can only see the surface of eggs and embryos, limiting the information available for selection. This study developed a new imaging system using optical coherence tomography (OCT) - the same technology used in eye exams - to see inside biological samples in three dimensions. The researchers created a special microscope setup that can quickly switch between different magnifications, allowing embryologists to first locate tiny samples in a large dish, then zoom in for detailed examination. They tested the system on artificial samples and pig eggs immersed in culture medium, successfully demonstrating its ability to capture internal structures without harming the samples. This technology could provide embryologists with much more information about egg and embryo quality, potentially improving selection and IVF success rates. The non-invasive nature of OCT means it could be used routinely without risking damage to precious eggs and embryos.